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XE-2100

Sysmex XE-2100™ Automated Hematology System

Fast, Accurate, Dependable

The XE-2100 Automated Hematology System is an easy to use, high volume analyzer with a history of reliability and productivity that provides operational efficiency for the hematology laboratory. Unique fluorescent flow cytometry and hydrodynamic focusing technologies enable the XE-2100 to minimize review rates and produce accurate results even when interferences are present.

Designed to be scalable, reliable and efficient, the Sysmex XE-2100 offers laboratories an automated hematology system that can truly meet and exceed their expectations. The XE-2100 streamlines your workflow by providing testing for up to 150 samples/hour, enabling rapid turnaround time.

Click here to download the brochure.

Features and Benefits
Specifications
Technology

Improves Productivity and Provides Enhanced Clinical Information

The Sysmex XE-2100 utilizes the power of fluorescent flow cytometry and hydrodynamic focusing technologies. Using a unique and advanced diode laser bench, Sysmex fluorescent flow cytometry provides the sensitivity needed for measuring and differentiating cell types in whole blood and body fluid samples. Fluorescent technology and hydrodynamic focusing enable the XE-2100 to consistently differentiate normal WBC, RBC and PLT populations from abnormal populations, thereby decreasing the number of manual interventions. The XE-2100 technology provides clinically relevant and reportable parameters.

Standard

Fluorescent NRBC count with excellent sensitivity and specificity to lower review rates

Provides improved low-end sensitivity
Enables rapid reporting
Provides efficient automated correction of WBC and differential results

Immature Granulocyte Count (IG% and #) offers reportable, quantitative results for metacyelocytes, myelocytes and promyelocytes

Reduce false positive and false negative rates
Obtain result consistency by reducing tech-to-tech variation in reporting manual differentials
Improve turnaround-time with fewer manual differentials

Platelet counts by a fluorescent optical method and by traditional impedance technology to improve accuracy of very low and very high PLT counts

Obtain accurate counts when interferences are present
Offers automated judgment for reporting PLT-O or PLT-I through instrument settings

Retic: Fluorescent reticulocyte count to reduce manual confirmation methods and their inherent errors

Eliminate common interferences to avoid manual counts
Improve immature reticulocyte information (IRF)

Reportable WBC and RBC counts for all common body fluid samples (CSF, synovial and serous)

Optional

RET-He: Reticulocyte Hemoglobin content measures the incorporation of iron into the red cell to assist the physician with anemia evaluation and management (e.g., functional iron deficiency anemia)

Provides rapid and direct analysis of an earlier stage of RBC development
Is an established parameter used in KDOQI (Kidney Disease Outcome Quality Initiative) guidelines for assessing the initial iron status of patients
Supports effective monitoring of costly drug protocols for cell stimulation

IPF: Immature Platelet Fraction to help the physician monitor thrombopoietic activity of the bone marrow

Ensures accuracy and sensitivity in measurement of immature platelets
Offers delineation of abnormal platelet populations seen by physicians in disease states such as AITP (autoimmune thrombocytopenic purpura) or TTP (thrombotic thrombocytopenic purpura)
Enables rapid reporting of results for prompt clinical information

HPC: Quantitative Hematopoietic Progenitor Cell count that can be used by physicians to determine the presence of hematopoietic progenitor cells in peripheral blood and cord blood samples

Offers quality information to better assist physicians with patient treatment protocols
Allows rapid analysis versus conventional methods for prompt determination of optimal stem cell harvest time
Reduces costs as the system does not require additional reagents, sample volume or specific technical expertise

Efficient, Fast and Reliable

31 Whole Blood Reportable Parameters	CBC with 6-part Differential including IG% and # 2 Platelet methods on-board. IPF is optional. Reticulocyte panel including RET%, RET#, IRF. RET-He is optional.
Body Fluid Reportable Parameters	WBC-BF, RBC-BF
Whole Blood Linearity	WBC: 0 – 440.00 x 10³/μL RBC: 0 – 8.00 x 10⁶/μL PLT: 0 – 5000 x 10³/μL
Body Fluid Linearity	WBC-BF: > 0.050 x 10³/μL RBC-BF: > 0.01 x 10⁶/μL
Throughput	Whole blood mode: 150 samples/hour (max.) Body fluid mode: 38 samples/hour (max.)
Sample Volume	Open mode: 200 μL Closed mode: 130 μL Capillary mode: 40 μL
Configuration	Standalone analyzer Sysmex XE-AlphaN™ Integrated Hematology System Sysmex HST-N™ Hematology Automation System

For additional specifications, refer to the product brochure.

Red Blood Cells and Platelets - RBCs and PLTs are counted in a dedicated channel using the direct current detection method with hydrodynamic focusing technology to minimize coincidence or recirculation. Automatic discriminators separate the two cell populations based on complex algorithms. The intensity of the electronic pulse from each analyzed RBC is proportional to the cell volume. The hematocrit (HCT) is directly determined based on the count and volume detection of each individual RBC. Even with samples at extremely low or unusually high concentrations, the Sysmex cell counters analyze RBCs and platelets with uncompromised precision and accuracy.

Hemoglobin Analysis - The Sysmex sodium lauryl sulfate (SLS) method for hemoglobin analysis is a non-cyanide method. Hemoglobin is determined in a separate channel, minimizing interference from high leukocyte concentrations. The SLS method shows excellent correlation with the reference method. With very short reaction times, this method is ideal for high throughput analyzers.

Fluorescent Flow Cytometry - Traditional flow cytometry is considered the best method for the differentiation of cell populations. However, it requires the use of costly antigen-antibody reagents and the procedures can be cumbersome and time consuming. Sysmex has refined basic techniques of flow cytometry and uses highly specific polymethine dyes to adapt that sophisticated technology to the high volume and automation requirements of the clinical lab. In order to meet the clinical demands for more accurate routine differentiation of normal and abnormal cells, flow applications using simple but sophisticated fluorescent dyes will continue to be expanded to fit the needs of routine CBC testing.

WBC Differential - Fluorescent labeling is a milestone for the routine WBC differential. Fluorescent measurement reveals the nucleus-plasma ratio of each individually stained cell, enabling the XE-Series analyzers to differentiate 6 reportable WBC populations. The combination of side scatter (inner complexity of the cell), forward scatter (volume) and fluorescence of nucleic acid material determines the classification of each WBC. The XE-Series utilizes an Adaptive Cluster Analysis System (ACAS) instead of conventional discriminators to separate cell populations into well defined clusters. This three-dimensional measurement of WBC provides an accurate and precise differential, even in highly pathological samples.

Reticulocytes and Platelets - Fluorescent technology is also used to offer efficient and reproducible analysis of the reticulocyte count and maturation stages. The advanced technology allows an accurate count of reticulocytes and fluorescent platelets, even in extremely low concentrations and in samples with giant platelets or red cell fragments. Due to higher fluorescent intensity of nucleated cells, such as leukocytes and nucleated red blood cells or red blood cells containing Howell-Jolly Bodies, these cells are distinctly separated from reticulocytes. The RNA/DNA content of reticulocytes decreases over time until they mature into erythrocytes that are without nucleic acid residues. A population of very early reticulocytes, the IRF (Immature Reticulocyte Fraction) is analyzed and reported, providing information about the rate of production of reticulocytes. In addition, measurement of the fluorescent platelets (PLT-O) can help resolve impedance platelet flags and reduce manual slide review.

Nucleated Red Blood Cells - The unique NRBC channel utilizes fluorescence and forward scatter light intensity to analyze each cell. These two parameters allow clear and reliable separation of leukocytes and NRBCs. Leukocytes bind more dye to membrane and nuclear proteins than do NRBC. Consequently, leukocytes show much higher fluorescence than NRBC. The smaller volume of the NRBC nuclei results in a distinct pattern and separation of the WBC cluster from the NRBC cluster. Even at low concentrations, excellent precision and reproducibility for NRBC counts are achieved.

How Can Sysmex Help My Lab Become More Efficient and Productive?

Sysmex provides a comprehensive line of products and services designed to streamline workflow and keep your hematology laboratory running smoothly.

Automating smear review is now within the reach of labs of all sizes. To learn more about the Sysmex SP-Series automated slide maker/stainer and how it can integrate seamlessly with the XE-Series analyzers, click here. To learn more about cell image analysis, click here.

Information integration is within your reach. Sysmex gives you a unique platform to achieve consolidated data management, a comprehensive set of complex rules and access to data across your enterprise regardless of the number of sites or the LIS involved. To learn more about upgrading your lab from simple instrument-based rules to a system-wide information management system, click here.

Complementary back up systems: Why have dissimilar back up analyzers when you could have the consistent operations, reagents, controls and technology across analyzer platforms. All the hematology analyzers that carry the respected Sysmex name are developed, manufactured and supported by Sysmex to give you comparable results and maximum productivity.

Sysmex HST-N™ and Sysmex XE-AlphaN™ for a Scalable Automation Solutions: Reliable automation platforms with integrated, automated slide making and staining that help laboratories work more efficiently. To learn more about these reliable automation platform, click here.

Microscopic urinalysis can be time consuming, unstandardized and fatiguing. To learn more about automating urine formed element analysis using fluorescent flow cytometry, click here.

The Sysmex Customer Resource Center (CRC) is your online portal to information and tools to get your lab started and support you every step of the way. The CRC offers complimentary webinars for continuing education for Sysmex customers and registered visitors. The extensive CRC document library provides and archive of tools and documents. The Insight™ Inter-laboratory Quality Assurance Program is also accessible to registered users through the CRC. To learn more about how you can get started using the Sysmex CRC today, click here.

Learning lasts a lifetime. To learn more about the educational programs available from the Sysmex CRC, click here.

To help you get started and to provide a high level of service throughout the life of your system, we provide you with an extensive array of service and support programs. To learn more about the services that support your system, click here.